Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: the profound effect of polarity on antiviral activity

J Med Chem. 1997 Nov 7;40(23):3707-11. doi: 10.1021/jm970522y.
No abstract available

MeSH terms

  • Animals
  • Anti-HIV Agents / chemical synthesis*
  • Anti-HIV Agents / pharmacokinetics
  • Anti-HIV Agents / pharmacology*
  • Chemical Phenomena
  • Chemistry, Physical
  • HIV Protease Inhibitors / chemical synthesis*
  • HIV Protease Inhibitors / pharmacokinetics
  • HIV Protease Inhibitors / pharmacology*
  • HIV-1 / drug effects
  • HIV-1 / enzymology*
  • Kinetics
  • Mice
  • Pyrones / chemical synthesis*
  • Pyrones / pharmacokinetics
  • Pyrones / pharmacology*
  • Structure-Activity Relationship

Substances

  • Anti-HIV Agents
  • HIV Protease Inhibitors
  • Pyrones